Metformin Efficiency in Genital Endometriosis Management

Study Objective: To assess clinical efficiency of combination therapy with Metformin and monotherapy in the management endometriosis genitalis externa (EGE). Design: perspective randomised singe-arm study parallel groups. Materials Methods. 146 patients pain syndrome associated endometreosis were treated one option for 6 months: Dienogest 2mg/d (group 1, n = 32); + 1,500mg/d 2, 61); 750mg/d 3, 29); 1,500 mg/d 4, 24). The intensity prevalence dysmenorrhea, dyspareunea, chronic pelvis (CPP) before after treatment evaluated. Results. In group became less intensive 85.2% EGE patients. Dysmenorrhea reduction was statistically more frequent (p 0.031), CPP 0.027), as compared to standard therapy. 75.9% 3 66.7% 4 had syndrome. There no significant differences results between monotherapy. Conclusion. Combination (2mg/day) (1,500mg/d) allows boosting endometreosis-associated Personification pathogen-specific individualised selection a drug dose is promising option. Keywords: endometreosis, syndrome, Dienogest,